The Relationship between Functional Promoter Variants of Macrophage Migration Inhibitory Factor and Endometriosis.

ABSTRACT:

Objective

Endometriosis is a common gynecological and inflammatory disorder. Macrophage migration inhibitory factor (MIF) is a key pro-inflammatory cytokine that is secreted by accumulated active macrophages in ectopic endometrial tissues. Two promoter polymorphisms of MIF [-794(CATT)_5-8 /-173G/C] were identified to susceptibility and severity of several immune and inflammatory diseases. We aimed to evaluate the possible association between MIF promoter polymorphisms and susceptibly to endometriosis and its corolation with mRNA level.

Materials and methods

This case-control study was performed in Royan Institute from 2015 to 2017. Polymorphisms were evaluated in 106 endometriosis patients and 110 controls. For 17 endometrioma tissues, gene expression

SUBMITTER: Chekini Z 

PROVIDER: S-EPMC7211282 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature