Vertebrate Lineages Exhibit Diverse Patterns of Transposable Element Regulation and Expression across Tissues.

ABSTRACT: Transposable elements (TEs) comprise a major fraction of vertebrate genomes, yet little is known about their expression and regulation across tissues, and how this varies across major vertebrate lineages. We present the first comparative analysis integrating TE expression and TE regulatory pathway activity in somatic and gametic tissues for a diverse set of 12 vertebrates. We conduct simultaneous gene and TE expression analyses to characterize patterns of TE expression and TE regulation across vertebrates and examine relationships between these features. We find remarkable variation in the expression of genes involved in TE negative regulation across tissues and species, yet consistently high expression in germline tissues, particularly in testes. Most vertebrates show comparably high leve

SUBMITTER: Pasquesi GIM 

PROVIDER: S-EPMC7211425 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature