Robust functional mapping of layer-selective responses in human lateral geniculate nucleus with high-resolution 7T fMRI.

ABSTRACT: The lateral geniculate nucleus (LGN) of the thalamus is the major subcortical relay of retinal input to the visual cortex. It plays important roles in visual perception and cognition and is closely related with several eye diseases and brain disorders. Primate LGNs mainly consist of six layers of monocular neurons with distinct cell types and functions. The non-invasive measure of layer-selective activities of the human LGN would have broad scientific and clinical implications. Using high-resolution functional magnetic resonance imaging (fMRI) at 7 Tesla (T) and carefully designed visual stimuli, we achieved robust functional mapping of eye-specific and also magnocellular/parvocellular-specific laminar patterns of the human LGN. These laminar patterns were highly reproducible with differen

SUBMITTER: Qian Y 

PROVIDER: S-EPMC7211434 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature