Effects of Lactobacillus pentosus in Children with Allergen-Sensitized Atopic Dermatitis.

ABSTRACT:

Background

Recent studies have shown that oral administration of probiotics may improve the immune imbalance caused by dysbiosis of the gut microbiome in atopic dermatitis (AD). This study aimed to investigate the clinical and immunological effects of Lactobacillus pentosus in children with mild to moderate AD.

Methods

Children aged 2-13 years with AD were randomized to receive either 1.0 × 10¹⁰ colony-forming units of L. pentosus or placebo, daily, for 12 weeks. The clinical severity of AD and transepidermal water loss were evaluated. Blood eosinophil counts, serum total immunoglobulin E (IgE), and cytokine levels were measured. The diversity and composition of the gut microbiota were also analyzed.

Results

Eighty-two children were recruited,

SUBMITTER: Ahn SH 

PROVIDER: S-EPMC7211510 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature