Modelling the impact of antibody-dependent enhancement on disease severity of Zika virus and dengue virus sequential and co-infection.

ABSTRACT: Human infections with viruses of the genus Flavivirus, including dengue virus (DENV) and Zika virus (ZIKV), are of increasing global importance. Owing to antibody-dependent enhancement (ADE), secondary infection with one Flavivirus following primary infection with another Flavivirus can result in a significantly larger peak viral load with a much higher risk of severe disease. Although several mathematical models have been developed to quantify the virus dynamics in the primary and secondary infections of DENV, little progress has been made regarding secondary infection of DENV after a primary infection of ZIKV, or DENV-ZIKV co-infection. Here, we address this critical gap by developing compartmental models of virus dynamics. We first fitted the models to published dat

SUBMITTER: Tang B 

PROVIDER: S-EPMC7211844 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature