A game-theoretic approach to deciphering the dynamics of amyloid-β aggregation along competing pathways.

ABSTRACT: Aggregation of amyloid-β (Aβ) peptides is a significant event that underpins Alzheimer's disease (AD). Aβ aggregates, especially the low-molecular weight oligomers, are the primary toxic agents in AD pathogenesis. Therefore, there is increasing interest in understanding their formation and behaviour. In this paper, we use our previously established results on heterotypic interactions between Aβ and fatty acids (FAs) to investigate off-pathway aggregation under the control of FA concentrations to develop a mathematical framework that captures the mechanism. Our framework to define and simulate the competing on- and off-pathways of Aβ aggregation is based on the principles of game theory. Together with detailed simulations and biophysical experiments, our m

SUBMITTER: Ghosh P 

PROVIDER: S-EPMC7211858 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature