Optimal control approaches for combining medicines and mosquito control in tackling dengue.

ABSTRACT: Dengue is a debilitating and devastating viral infection spread by mosquito vectors, and over half the world's population currently live at risk of dengue (and other flavivirus) infections. Here, we use an integrated epidemiological and vector ecology framework to predict optimal approaches for tackling dengue. Our aim is to investigate how vector control and/or vaccination strategies can be best combined and implemented for dengue disease control on small networks, and whether these optimal strategies differ under different circumstances. We show that a combination of vaccination programmes and the release of genetically modified self-limiting mosquitoes (comparable to sterile insect approaches) is always considered the most beneficial strategy for reducing the number of infected individu

SUBMITTER: Rawson T 

PROVIDER: S-EPMC7211884 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature