Whole-slice mapping of GABA and GABA⁺ at 7T via adiabatic MEGA-editing, real-time instability correction, and concentric circle readout.

ABSTRACT: An adiabatic MEscher-GArwood (MEGA)-editing scheme, using asymmetric hyperbolic secant editing pulses, was developed and implemented in a B₁⁺-insensitive, 1D-semiLASER (Localization by Adiabatic SElective Refocusing) MR spectroscopic imaging (MRSI) sequence for the non-invasive mapping of γ-aminobutyric acid (GABA) over a whole brain slice. Our approach exploits the advantages of edited-MRSI at 7T while tackling challenges that arise with ultra-high-field-scans. Spatial-spectral encoding, using density-weighted, concentric circle echo planar trajectory readout, enabled substantial MRSI acceleration and an improved point-spread-function, thereby reducing extracranial lipid signals. Subject motion and scanner instabilities were corrected in real-time using volumetric na

SUBMITTER: Moser P 

PROVIDER: S-EPMC7212034 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature