Haemostatic biomarkers for prognosis and prediction of therapy response in patients with metastatic colorectal cancer.

ABSTRACT:

Background

Haemostatic activation and hypercoagulability are frequently observed in patients with metastatic colorectal cancer (mCRC), increase risk of venous thromboembolism (VTE) and have been implicated in tumour proliferation and progression. To date, the association of haemostatic biomarkers with oncologic outcomes including overall survival (OS), progression free survival (PFS) and disease control rate (DCR) is incompletely understood.

Methods

Within the framework of the Vienna Cancer and Thrombosis Study, a prospective observational cohort study, we conducted an exploratory analysis to investigate the association of six known biomarkers of haemostasis with oncologic outcomes in 99 patients with mCRC prior to chemotherapy initiation.

Results

Patients with high l

SUBMITTER: Moik F 

PROVIDER: S-EPMC7212083 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature