Impact of normothermic ex vivo lung perfusion on early post-transplantation cytomegalovirus infection.

ABSTRACT:

Background

The low acceptance rates in lung transplantation underline the importance to use every potential transplantable organ. With the use of normothermic ex vivo lung perfusion (EVLP) there is a potential to use more donor lungs for transplantation. Aim of this study was to evaluate if EVLP has an effect on cytomegalovirus (CMV) infection after lung transplantation.

Methods

Between May 2016 and October 2018, 57 lung transplants were performed. Out of these 21 extended criteria lungs were evaluated by EVLP and 16 transplanted. In a retrospective study, results of EVLP treated lungs were compared with lungs after cold storage preservation (CSP). Donor/recipient CMV IgG status and seroconversion rate was examined.

Results

Donors were CMV IgG+ in EVLP 69% and

SUBMITTER: Koch A 

PROVIDER: S-EPMC7212143 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature