Prophylactic effects of biogenic selenium nanoparticles on acute toxoplasmosis: An in vivo study.

ABSTRACT:

Background

In this investigation, the in vivo efficacy and safety of biogenic selenium nanoparticles (SeNPs) are assessed against acute toxoplasmosis caused by Toxoplasma gondii (Sarcocystidae) in the mice.

Methods

Male NMRI mice were orally treated with normal saline (control group) and SeNPs at the doses of 5 and 10 mg/kg once a day for 14 days. On the 15th day, the mice were infected with 10⁴ tachyzoites of T. gondii RH strain by the intraperitoneal route. The mortality rate and parasite load were determined in the infected mice. The mRNA levels of IFN-γ, IL10, IL12, and inducible nitric oxide synthase were also examined in the infected mice by quantitative real-time PCR.

Results

The rate of mortality in the infected mice receiving S

SUBMITTER: Shakibaie M 

PROVIDER: S-EPMC7212177 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature