Protocol and recruitment results from a 13-week randomized controlled trial comparing the effects of different doses of nitrate-rich beetroot juice on cognition, cerebral blood flow and peripheral vascular function in overweight and obese older people.

ABSTRACT:

Background

Nitrate-rich food can increase NO production and may induce positive effects on brain function. This study examined the feasibility of a randomized clinical trial (RCT) testing the effects of prolonged consumption of incremental doses of dietary nitrate (NO₃ ^-) in overweight and obese older participants. Secondary aims tested dose-dependent changes in cognitive, vascular and pulmonary functions and cerebral blood flow (CBF).

Methods

This was a single blind, four-arm parallel RCT conducted in 60 overweight and obese older participants. Eligible participants were randomized to:1) high NO₃ ^- (140 ml of beetroot juice (BJ) per day, ~800 mg of NO₃ ^-/day), 2) moderate NO₃ ^- (70 ml of

SUBMITTER: Babateen AM 

PROVIDER: S-EPMC7212182 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature