Developmental maturation of inhibitory control circuitry in a high-risk sample: A longitudinal fMRI study.

ABSTRACT:

Background

The goal of this work was to characterize the maturation of inhibitory control brain function from childhood to early adulthood using longitudinal data collected in two cohorts.

Methods

Functional MRI during a go/no-go task was conducted in 290 participants, with 88 % undergoing repeated scanning at 1- to 2-year intervals. One group entered the study at age 7-13 years (n = 117); the other entered at age 18-23 years (n = 173). 33.1 % of the sample had two parents with a substance use disorder (SUD), 43.8 % had one parent with an SUD, and 23.1 % had no parents with an SUD. 1162 scans were completed, covering ages 7-28, with longitudinal data from the cohorts overlapping across ages 16-21. A marginal model with sandwich estimator standard errors was used to character

SUBMITTER: Cope LM 

PROVIDER: S-EPMC7212183 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature