Analysis of the association between the XRCC2 rs3218536 polymorphism and ovarian cancer risk.

ABSTRACT:

Introduction

Results conflict on the association between the XRCC2 rs3218536 polymorphism and ovarian cancer risk, despite wide-ranging investigations. This meta-analysis examines whether the XRCC2 rs3218536 polymorphism is associated with ovarian cancer risk.

Material and methods

Eligible case-control studies were searched in PubMed. We therefore performed a meta-analysis of 5,802 ovarian cancer cases and 9,390 controls from 7 articles published. The strength of association between XRCC2 rs3218536 polymorphism and ovarian cancer susceptibility was calculated using pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs).

Results

No statistically significant associations between XRCC2 rs3218536 polymorphism and ovarian cancer risk were found in any g

SUBMITTER: Yuan C 

PROVIDER: S-EPMC7212224 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature