Schizophrenia-associated MicroRNA-Gene Interactions in the Dorsolateral Prefrontal Cortex.

ABSTRACT: Schizophrenia-associated anomalies in gene expression in postmortem brain can be attributed to a combination of genetic and environmental influences. Given the small effect size of common variants, it is likely that we may only see the combined impact of some of these at the pathway level in small postmortem studies. At the gene level, however, there may be more impact from common environmental exposures mediated by influential epigenomic modifiers, such as microRNA (miRNA). We hypothesise that dysregulation of miRNAs and their alteration of gene expression have significant implications in the pathophysiology of schizophrenia. In this study, we integrate changes in cortical gene and miRNA expression to identify regulatory interactions and networks associated with the disorder. Gene express

SUBMITTER: Santarelli DM 

PROVIDER: S-EPMC7212302 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature