An Integrative Network Modeling Approach to T CD4 Cell Activation.

ABSTRACT: The adaptive immune response is initiated by the interaction of the T cell antigen receptor/CD3 complex (TCR) with a cognate peptide bound to a MHC molecule. This interaction, along with the activity of co-stimulatory molecules and cytokines in the microenvironment, enables cells to proliferate and produce soluble factors that stimulate other branches of the immune response for inactivation of infectious agents. The intracellular activation signals are reinforced, amplified and diversified by a complex network of biochemical interactions, and includes the activity of molecules that modulate the activation process and stimulate the metabolic changes necessary for fulfilling the cell energy demands. We present an approach to the analysis of the main early signaling events of T cell activatio

SUBMITTER: Martinez-Mendez D 

PROVIDER: S-EPMC7212416 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature