Exact Distribution of Linkage Disequilibrium in the Presence of Mutation, Selection, or Minor Allele Frequency Filtering.

ABSTRACT: Linkage disequilibrium (LD), often expressed in terms of the squared correlation (r 2) between allelic values at two loci, is an important concept in many branches of genetics and genomics. Genetic drift and recombination have opposite effects on LD, and thus r 2 will keep changing until the effects of these two forces are counterbalanced. Several approximations have been used to determine the expected value of r 2 at equilibrium in the presence or absence of mutation. In this paper, we propose a probability-based approach to compute the exact distribution of allele frequencies at two loci in a finite population at any generation t conditional on the distribution at generation t - 1. As r 2 is a function of this distribution of allele frequencies, this approach can be used to examine the d

SUBMITTER: Qu J 

PROVIDER: S-EPMC7212447 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature