Uncovering sex-specific mechanisms of action of testosterone and redox balance.

ABSTRACT: The molecular and pharmacological manipulation of the endogenous redox system is a promising therapy to limit myocardial damage after a heart attack; however, antioxidant therapies have failed to fully establish their cardioprotective effects, suggesting that additional factors, including antioxidant system interactions with other molecular pathways, may alter the pharmacological effects of antioxidants. Since gender differences in cardiovascular disease (CVD) are prevalent, and sex is an essential determinant of the response to oxidative stress, it is of particular interest to understand the effects of sex hormone signaling on the activity and expression of cellular antioxidants and the pharmacological actions of antioxidant therapies. In the present review, we briefly summarize the curre

SUBMITTER: Cruz-Topete D 

PROVIDER: S-EPMC7212492 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature