Measures of Adiposity and Alzheimer's Disease-Related MRI Markers: The Northern Manhattan Study.

ABSTRACT:

Background

Adiposity may increase risk for dementia and Alzheimer's disease (AD), but mechanisms are unclear.

Objective

To examine associations between measures of adiposity with AD-signature region cortical thickness and hippocampal volume.

Methods

We used data from the Northern Manhattan Study, a clinically stroke-free cohort of mostly Hispanic participants. Exposures of interest included body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC), and adiponectin concentration, measured at study entry. AD-signature region cortical thickness and hippocampal volume were obtained using Freesurfer. We estimated associations using multivariable linear regression, adjusting for sociodemographics and health behaviors. We re-examined estimates after adjustment f

SUBMITTER: Caunca MR 

PROVIDER: S-EPMC7212498 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature