The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca²⁺-NFATc1 axis.

ABSTRACT: Dynamic regulation of the mitochondrial network by mitofusins (MFNs) modulates energy production, cell survival, and many intracellular signaling events, including calcium handling. However, the relative importance of specific mitochondrial functions and their dependence on MFNs vary greatly among cell types. Osteoclasts have many mitochondria, and increased mitochondrial biogenesis and oxidative phosphorylation enhance bone resorption, but little is known about the mitochondrial network or MFNs in osteoclasts. Because expression of each MFN isoform increases with osteoclastogenesis, we conditionally deleted MFN1 and MFN2 (double conditional KO (dcKO)) in murine osteoclast precursors, finding that this increased bone mass in young female mice and abolished osteoclast precursor differentiat

SUBMITTER: Ballard A 

PROVIDER: S-EPMC7212632 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature