Genomic characterization of high-recurrence risk papillary thyroid carcinoma in a southern Chinese population.

ABSTRACT:

Background

The objective of this study was to investigate genetic variations and the relationships between these genetic variations and clinicopathological features of high-recurrence risk papillary thyroid carcinoma in a southern Chinese population.

Methods

One hundred sixty-eight patients of high-recurrence risk papillary thyroid carcinoma were recruited for this study from 2017 to 2018. Formalin-fixed paraffin-embedded tissue and the data of clinicopathological characteristics were all collected and analyzed from these patients. We used next-generation sequencing technology to investigate the targeted gene mutations and gene fusions of the pathology specimens.

Results

The frequency of candidate tumor driver gene mutation was 85.1% in 143 patients, including BRAF V6

SUBMITTER: Li M 

PROVIDER: S-EPMC7212670 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature