Efficacy of ruthenium coordination complex-based Rutherrin in a preclinical rat glioblastoma model.

ABSTRACT:

Background

Glioblastoma is an aggressive brain cancer in adults with a grave prognosis, aggressive radio and chemotherapy provide only a 15 months median survival.

Methods

We evaluated the tolerability and efficacy of the Ruthenium-based photosensitizer TLD-1433 with apo-Transferrin (Rutherrin) in the rat glioma 2 (RG-2) model. The specific tumor uptake ratio and photodynamic therapy (PDT) threshold of the rat glioblastoma and normal brain were determined, survival and CD8⁺T-cell infiltration post-therapy were analyzed. Results were compared with those obtained for 5-aminolevulinic acid (ALA)-induced Protoporphyrin IX (PpIX)-mediated photodynamic therapy in the same animal model. As both photosensitizers have different photophysical properties, the number of absor

SUBMITTER: Munegowda MA 

PROVIDER: S-EPMC7212850 | biostudies-literature | 2019 May-Dec

REPOSITORIES: biostudies-literature