Conventional MRI radiomics in patients with suspected early- or pseudo-progression.

ABSTRACT:

Background

After radiochemotherapy, 30% of patients with early worsening MRI experience pseudoprogression (Psp) which is not distinguishable from early progression (EP). We aimed to assess the diagnostic value of radiomics in patients with suspected EP or Psp.

Methods

Radiomics features (RF) of 76 patients (53 EP and 23 Psp) retrospectively identified were extracted from conventional MRI based on four volumes-of-interest. Subjects were randomly assigned into training and validation groups. Classification model (EP versus Psp) consisted of a random forest algorithm after univariate filtering. Overall (OS) and progression-free survivals (PFS) were predicted using a semi-supervised principal component analysis, and forecasts were evaluated using C-index and integrated Brier sco

SUBMITTER: Bani-Sadr A 

PROVIDER: S-EPMC7212855 | biostudies-literature | 2019 May-Dec

REPOSITORIES: biostudies-literature