MR-guided focused ultrasound increases antibody delivery to nonenhancing high-grade glioma.

ABSTRACT:

Background

High-grade glioma (HGG) remains a recalcitrant clinical problem despite many decades of research. A major challenge in improving prognosis is the inability of current therapeutic strategies to address a clinically significant burden of infiltrating tumor cells that extend beyond the margins of the primary tumor mass. Such cells cannot be surgically excised nor efficiently targeted by radiation therapy. Therapeutic targeting of this tumor cell population is significantly hampered by the presence of an intact blood-brain barrier (BBB). In this study, we performed a preclinical investigation of the efficiency of MR-guided Focused Ultrasound (FUS) to temporarily disrupt the BBB to allow selective delivery of a tumor-targeting antibody to infiltrating tumor.

Methods

St

SUBMITTER: Brighi C 

PROVIDER: S-EPMC7212871 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature