Constitutive activation of the EGFR-STAT1 axis increases proliferation of meningioma tumor cells.

ABSTRACT:

Background

Meningiomas are the most frequent primary brain tumors of the central nervous system. The standard of treatment is surgery and radiotherapy, but effective pharmacological options are not available yet. The well-characterized genetic background stratifies these tumors in several subgroups, thus increasing diversification. We identified epidermal growth factor receptor-signal transducer and activator of transcription 1 (EGFR-STAT1) overexpression and activation as a common identifier of these tumors.

Methods

We analyzed STAT1 overexpression and phosphorylation in 131 meningiomas of different grades and locations by utilizing several techniques, including Western blots, qPCR, and immunocytochemistry. We also silenced and overexpressed wild-type and mutant forms of th

SUBMITTER: Ferluga S 

PROVIDER: S-EPMC7212880 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature