Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China.

ABSTRACT:

Background

Crucial roles of hematologic and immunologic responses in progression of coronavirus disease 2019 (COVID-19) remain largely unclear.

Objective

We sought to address the dynamic changes in hematologic and immunologic biomarkers and their associations with severity and outcomes of COVID-19.

Methods

A retrospective study including 548 patients with COVID-19 with clarified outcome (discharged or deceased) from a national cohort in China was performed. Cross-sectional and longitudinal variations were compared and the associations with different severity and outcomes were analyzed.

Results

On admission, the counts of lymphocytes, T-cell subsets, eosinophils, and platelets decreased markedly, especially in severe/critical and fatal patients. Increased neutro

SUBMITTER: Chen R 

PROVIDER: S-EPMC7212968 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature