TP53 rs1042522 polymorphism and early-onset breast cancer.

ABSTRACT:

Background

Breast cancer is the leading cause of cancer deaths among women. Early-onset breast cancer is well recognized as it clinically differs from old-age diagnosed breast neoplasms. TP53 rs1042522 polymorphism relates to the risk of breast neoplasms, but this relationship in Turkish early-onset breast cancer patients has not been investigated yet. We aimed to search the relationship between TP53 rs1042522 polymorphism and young Turkish breast cancer patients.

Materials and methods

Ninety-six female breast cancer patients who were ≤ 40 years of age and 96 healthy controls were enrolled in our study. Participants were genotyped by the hybridization probe system.

Results

We identified that the genotype frequencies of rs1042522 were significantly

SUBMITTER: Icen-Taskin I 

PROVIDER: S-EPMC7213006 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature