A Modular Construction of Epidithiodiketopiperazines.

ABSTRACT: Epidithiodiketopiperazines (ETPs) possess remarkably diverse biological activities and have attracted significant synthetic attention. The preparation of analogues is actively pursued; however, they are structurally challenging, and more direct and modular methods for their synthesis are desirable. To this end, the utility of a bifunctional triketopiperazine building block for the straightforward synthesis of ETPs is reported. A modular strategy consisting of enolate alkylation followed by site-selective nucleophile addition enables the concise synthesis of (±)-hyalodendrin and a range of analogues.

SUBMITTER: Snaddon TN 

PROVIDER: S-EPMC7213270 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature