Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.

ABSTRACT: The signaling cascade induced by the interaction of erythropoietin (EPO) with its receptor (EPO-R) is a key event of erythropoiesis. We present here data indicating that Fyn, a Src-family-kinase, participates in the EPO signaling-pathway, since Fyn^-/- mice exhibit reduced Tyr-phosphorylation of EPO-R and decreased STAT5-activity. The importance of Fyn in erythropoiesis is also supported by the blunted responsiveness of Fyn^-/- mice to stress erythropoiesis. Fyn^-/- mouse erythroblasts adapt to reactive oxygen species (ROS) by activating the redox-related-transcription-factor Nrf2. However, since Fyn is a physiologic repressor of Nrf2, absence of Fyn resulted in persistent-activation of Nrf2 and accumulation of nonfunctional proteins. ROS-induced over-activati

SUBMITTER: Beneduce E 

PROVIDER: S-EPMC7213426 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature