Blood-brain barrier opening with focused ultrasound in experimental models of Parkinson's disease.

ABSTRACT: Parkinson's disease has many symptomatic treatments, but there is no neuroprotective therapy currently available. The evolution of this disease is inexorably progressive, and halting or stopping the neurodegenerative process is a major unmet need. Parkinson's disease motor features at onset are typically limited to 1 body segment, that is, focal signs, and the nigrostriatal degeneration is highly asymmetrical and mainly present in the caudal putamen. Thus, clinically and neurobiologically the process is fairly limited early in its evolution. Tentatively, this would allow the possibility of intervening to halt neurodegeneration at the most vulnerable site. The recent use of new technologies such as focused ultrasound provides interesting prospects. In particular, the possibility of transien

SUBMITTER: Karakatsani ME 

PROVIDER: S-EPMC7213581 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature