Factors Associated with Declining to Participate in a Pediatric Oncology Next Generation Sequencing Study.

ABSTRACT:

Purpose

For the advances of pediatric oncology next generation sequencing (NGS) research to equitably benefit all children, a diverse and representative sample of participants is needed. However, little is known about demographic and clinical characteristics that differentiate families who decline enrollment in pediatric oncology NGS research.

Methods

Demographic and clinical data were retrospectively extracted for 363 pediatric oncology patients (0-21 years) approached for enrollment on Genomes for Kids (G4K), a study examining the feasibility of comprehensive clinical genomic analysis of tumors and paired normal samples. Demographic and clinical factors that significantly differentiated which families declined were subsequently compared to enrollment in Clinical Implementa

SUBMITTER: Howard Sharp KM 

PROVIDER: S-EPMC7213582 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature