Activity of Vincristine and Irinotecan in Diffuse Anaplastic Wilms Tumor and Therapy Outcomes of Stage II to IV Disease: Results of the Children's Oncology Group AREN0321 Study.

ABSTRACT:

Purpose

AREN0321 evaluated the activity of vincristine and irinotecan (VI) in patients with newly diagnosed diffuse anaplastic Wilms tumor (DAWT) and whether a regimen containing carboplatin (regimen UH1) in addition to regimen I agents used in the National Wilms Tumor Study 5 (NWTS-5; vincristine, doxorubicin, cyclophosphamide, and etoposide plus radiotherapy) would improve patient outcomes.

Patients and methods

Patients with stage II to IV DAWT without measurable disease received regimen UH1. Patients with stage IV measurable disease were eligible to receive VI (vincristine, 1.5 mg/m² per day intravenously on days 1 and 8; irinotecan, 20 mg/m² per day intravenously on days 1-5 and 8-12 of a 21-day cycle) in an upfront window; those with complete (CR)

SUBMITTER: Daw NC 

PROVIDER: S-EPMC7213587 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature