Investigating gene-microRNA networks in atrial fibrillation patients with mitral valve regurgitation.

ABSTRACT:

Background

Atrial fibrillation (AF) is predicted to affect around 17.9 million individuals in Europe by 2060. The disease is associated with severe electrical and structural remodelling of the heart, and increased the risk of stroke and heart failure. In order to improve treatment and find new drug targets, the field needs to better comprehend the exact molecular mechanisms in these remodelling processes.

Objectives

This study aims to identify gene and miRNA networks involved in the remodelling of AF hearts in AF patients with mitral valve regurgitation (MVR).

Methods

Total RNA was extracted from right atrial biopsies from patients undergoing surgery for mitral valve replacement or repair with AF and without history of AF to test for differentially expressed genes and

SUBMITTER: Larupa Santos J 

PROVIDER: S-EPMC7213724 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature