Potency and breadth of human primary ZIKV immune sera shows that Zika viruses cluster antigenically as a single serotype.

ABSTRACT: Zika virus (ZIKV) emerged as a global public health threat throughout the Americas since 2014. Phylogenetically, the virus is composed of three main lineages, an African, Asian, and American lineage. The recent emergence and spread of ZIKV has raised questions regarding the breadth and potency of human primary ZIKV immune sera against antigenically diverse ZIKV. Although ZIKV is thought to compose a single antigenic serotype, in-depth evaluation of the antigenic relatedness of ZIKV across genetic variants has been limited to a relatively small series of early convalescent human immune sera (4-12 weeks) against a limited number (3) of genetic variants. Using virus neutralization assays, we characterize the potency and breadth of twelve primary ZIKV immune sera from adults infected 5 to 38 m

SUBMITTER: Nix CD 

PROVIDER: S-EPMC7213746 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature