Tally-2.0: upgraded validator of tandem repeat detection in protein sequences.

ABSTRACT:

Motivation

Proteins containing tandem repeats (TRs) are abundant, frequently fold in elongated non-globular structures and perform vital functions. A number of computational tools have been developed to detect TRs in protein sequences. A blurred boundary between imperfect TR motifs and non-repetitive sequences gave rise to necessity to validate the detected TRs.

Results

Tally-2.0 is a scoring tool based on a machine learning (ML) approach, which allows to validate the results of TR detection. It was upgraded by using improved training datasets and additional ML features. Tally-2.0 performs at a level of 93% sensitivity, 83% specificity and an area under the receiver operating characteristic curve of 95%.

Availability and implementation

Tally-2.0 is available, as a web

SUBMITTER: Perovic V 

PROVIDER: S-EPMC7214015 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature