Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.

ABSTRACT: The influenza virus is one of the major public health threats. However, the development of efficient vaccines and therapeutic drugs to combat this virus is greatly limited by its frequent genetic mutations. Because of this, targeting the host factors required for influenza virus replication may be a more effective strategy for inhibiting a broader spectrum of variants. Here, we demonstrated that inhibition of a motor protein kinesin family member 18A (KIF18A) suppresses the replication of the influenza A virus (IAV). The expression of KIF18A in host cells was increased following IAV infection. Intriguingly, treatment with the selective and ATP-competitive mitotic kinesin KIF18A inhibitor BTB-1 substantially decreased the expression of viral RNAs and proteins, and the production of infectio

SUBMITTER: Cho YB 

PROVIDER: S-EPMC7214149 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature