Characterization of the relationship between FLI1 and immune infiltrate level in tumour immune microenvironment for breast cancer.

ABSTRACT: Breast cancer is the most common cancer and the leading cause of cancer death among women in the world. Tumour-infiltrating lymphocytes were defined as the white blood cells left in the vasculature and localized in tumours. Recently, tumour-infiltrating lymphocytes were found to be associated with good prognosis and response to immunotherapy in tumours. In this study, to examine the influence of FLI1 in immune system in breast cancer, we interrogated the relationship between the FLI1 expression levels with infiltration levels of 28 immune cell types. By splitting the breast cancer samples into high and low expression FLI1 subtypes, we found that the high expression FLI1 subtype was enriched in many immune cell types, and the up-regulated differentially expressed genes between them were enr

SUBMITTER: Wang S 

PROVIDER: S-EPMC7214163 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature