Noncanonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure.

ABSTRACT:

Background

Control of the inflammatory response is critical to maintaining homeostasis, and failure to do so contributes to the burden of chronic inflammation associated with several disease states. The mechanisms that underlie immunosuppression, however, remain largely unknown. Although defects in autophagy machinery have been associated with inflammatory pathologic conditions, we now appreciate that autophagic components participate in noncanonical pathways distinct from classical autophagy. We have previously demonstrated that LC3-associated phagocytosis (LAP), a noncanonical autophagic process dependent on Rubicon (rubicon autophagy regulator [RUBCN]), contributes to immunosuppression.

Objective

We used Rubcn^-/- mice to examine the role of the LAP pathway in m

SUBMITTER: Sil P 

PROVIDER: S-EPMC7214202 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature