Cognitive Modeling Informs Interpretation of Go/No-Go Task-Related Neural Activations and Their Links to Externalizing Psychopathology.

ABSTRACT:

Background

Individuals with attention-deficit/hyperactivity disorder and other externalizing psychopathologies tend to display poor behavioral performance on the go/no-go task, which is thought to reflect deficits in inhibitory control. However, clinical neuroimaging studies using this task have yielded conflicting results, raising basic questions about what the task measures and which aspects of the task relate to clinical outcomes. We used computational modeling to provide a clearer understanding of how neural activations from this task relate to the cognitive mechanisms that underlie performance and to probe the implications of these relationships for clinical research.

Methods

A total of 143 young adults (8-21 years of age) performed the go/no-go task during functional m

SUBMITTER: Weigard A 

PROVIDER: S-EPMC7214209 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature