Risk of major cardiovascular and neurologic events with obstructive sleep apnea among patients with atrial fibrillation.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is a known risk factor for atrial fibrillation (AF). However, it remains unclear whether OSA is independently associated with worse cardiovascular and neurological outcomes in patients with AF.

Methods

We used the ORBIT-AF I and ORBIT-AF II to conduct a retrospective cohort study of 22,760 patients with AF with and without OSA. Adjusted multivariable Cox proportional hazards models was used to determine whether OSA was associated with increased risk for major adverse cardiac and neurologic events (MACNEs) (cardiovascular death, myocardial infarction, stroke/transient ischemic attack/non-central nervous system embolism (stroke/SE), and new-onset heart failure], combined and individually.

Results

A total of 4,045 (17.8%) patients

SUBMITTER: Dalgaard F 

PROVIDER: S-EPMC7214210 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature