Efficient treatment of murine acute GvHD by in vitro expanded donor regulatory T cells.

ABSTRACT: Acute graft-versus-host disease (aGvHD) is a frequent complication after allogeneic bone marrow/stem cell transplantation (BMT/SCT) induced by co-transplanted alloreactive conventional donor T cells. We previously demonstrated that the adoptive transfer of donor CD4⁺CD25⁺Foxp3⁺ regulatory T cells (Treg) at the time of BMT prevents aGvHD in murine models. Yet, the therapeutic potential of donor Treg for the treatment of established aGvHD has not yet been studied in detail. We now used in vitro expanded phenotypically and functionally stable murine Treg to explore their therapeutic efficacy in haploidentical aGvHD models. Upon transfer donor Treg ameliorate clinical and histologic signs of aGvHD and significantly improve survival. They migrate to lymphoid as

SUBMITTER: Riegel C 

PROVIDER: S-EPMC7214258 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature