Remdesivir in COVID-19: A critical review of pharmacology, pre-clinical and clinical studies.

ABSTRACT:

Background & aims

Remdesivir is a broad spectrum anti-viral drug that has shown to inhibit SARS-CoV-2, in vitro and in vivo. In absence of any effective treatment for SARS-CoV-2 infection (COVID-19), remdesivir has been tried for a compassionate use in severe COVID-19. Newer randomized controlled studies that have recently become available, showed a mixed result. We aimed to systematically search the literature to understand the pharmacology and clinical effects of remdesivir in patients with COVID-19.

Methods

We systematically searched the PubMed, ClinicalTrial.Org and MedRxiv database up till May 5, 2020 using specific key words such as "Remdesivir" or 'GS-5734″ AND "COVID-19" or "SARS-CoV-2" and retrieved all the article published in English language, that have reported t

SUBMITTER: Singh AK 

PROVIDER: S-EPMC7214279 | biostudies-literature | 2020 Jul - Aug

REPOSITORIES: biostudies-literature