The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic.

ABSTRACT:

Background

SARS-CoV-2 viral infection causes COVID-19 that can result in severe acute respiratory distress syndrome (ARDS), which can cause significant mortality, leading to concern that immunosuppressive treatments for multiple sclerosis and other disorders have significant risks for both infection and ARDS.

Objective

To examine the biology that potentially underpins immunity to the SARS-Cov-2 virus and the immunity-induced pathology related to COVID-19 and determine how this impinges on the use of current disease modifying treatments in multiple sclerosis.

Observations

Although information about the mechanisms of immunity are scant, it appears that monocyte/macrophages and then CD8 T cells are important in eliminating the SARS-CoV-2 virus. This may be facilitated vi

SUBMITTER: Baker D 

PROVIDER: S-EPMC7214323 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature