Plasmonic biosensors fabricated by galvanic displacement reactions for monitoring biomolecular interactions in real time.

ABSTRACT: Optical sensors are prepared by reduction of gold ions using freshly etched hydride-terminated porous silicon, and their ability to specifically detect binding between protein A/rabbit IgG and asialofetuin/Erythrina cristagalli lectin is studied. The fabrication process is simple, fast, and reproducible, and does not require complicated lab equipment. The resulting nanostructured gold layer on silicon shows an optical response in the visible range based on the excitation of localized surface plasmon resonance. Variations in the refractive index of the surrounding medium result in a color change of the sensor which can be observed by the naked eye. By monitoring the spectral position of the localized surface plasmon resonance using reflectance spectroscopy, a bulk sensitivity of 296 nm ± 3 

SUBMITTER: Pacholski C 

PROVIDER: S-EPMC7214386 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature