Layer 4 pyramidal neuron dendritic bursting underlies a post-stimulus visual cortical alpha rhythm.

ABSTRACT: Alpha rhythms (9-11 Hz) are a dominant feature of EEG recordings, particularly over occipital cortex on cessation of a visual stimulation. Little is known about underlying neocortical mechanisms so here we constructed alpha rhythm models that follow cessation of cortical stimulation. The rhythm manifests following a period of gamma frequency activity in local V1 networks in layer 4. It associates with network level bias of excitatory synaptic activity in favour of NMDA- rather than AMPA-mediated signalling and reorganisation of synaptic inhibition in favour of fast GABA_A receptor-mediated events. At the cellular level the alpha rhythm depended upon the generation of layer 4 pyramidal neuron dendritic bursting mediated primarily by PPDA-sensitive NR2C/D-containing NMDA receptors,

SUBMITTER: Traub RD 

PROVIDER: S-EPMC7214406 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature