Landiolol hydrochloride for prevention of atrial fibrillation during esophagectomy: a randomized controlled trial.

ABSTRACT: INTRODUCTION:Landiolol hydrochloride reduces the incidence of perioperative atrial fibrillation (AF) in cardiac surgery; however, little evidence is available regarding its effects in other types of surgery, including esophagectomy. We assessed the hypothesis that landiolol reduces perioperative AF and other complications associated with esophagectomy. METHODS:This single-center, randomized, double-blind, parallel-group study enrolled patients scheduled for esophagectomy. Patients were divided into those given landiolol at 3 μg/kg/min or placebo for 24 h. The primary outcome was the proportion of patients who developed AF within 96 h starting at 9:00 AM on the day of surgery. The secondary outcomes were the proportion of patients whose AF appeared within 24 h, other complications based on

SUBMITTER: Aoki Y 

PROVIDER: S-EPMC7214548 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature