CRISPR/Cas9 for overcoming drug resistance in solid tumors.

ABSTRACT:

Objectives

In this review, we focus on the application of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated nuclease 9 (Cas9), as a powerful genome editing system, in the identification of resistance mechanisms and in overcoming drug resistance in the most frequent solid tumors.

Data acquisition

Data were collected by conducting systematic searching of scientific English literature using specific keywords such as "cancer", "CRISPR" and related combinations.

Results

The review findings revealed the importance of CRISPR/Cas9 system in understanding drug resistance mechanisms and identification of resistance-related genes such as PBRM1, SLFN11 and ATPE1 in different cancers. We also provided an overview of genes, including RSF1, CDK5, a

SUBMITTER: Saber A 

PROVIDER: S-EPMC7214581 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature