A new derivative of acetylsalicylic acid and carnosine: synthesis, physical and chemical properties, biological activity.

ABSTRACT:

Purpose

The aim of this study was to create and assess biological activity of a new compound based on carnosine and acetylsalicylic acid (ASA) that will comprise antioxidant effect with antiplatelet activity, while simultaneously preventing side effects on the gastrointestinal tract.

Methods

Salicyl-carnosine (SC) was synthesized by condensation of ASA and carnosine. Antioxidant activity was determined by spectrophotometric and chemiluminescence methods. Antiplatelet activity was carried out by the light transmission-aggregometry method using the inductor ADP. Chronic gastric ulcer in rats was modeled using glacial acetic acid.

Results

Using SOD-like activity, iron-induced chemiluminescence, BaSO4-activated respiratory burst, and evaluation of red blood cell structure

SUBMITTER: Kulikova OI 

PROVIDER: S-EPMC7214588 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature