Study on the interaction of triaryl-dihydro-1,2,4-oxadiazoles with α-glucosidase.

ABSTRACT:

Purpose

One of the therapeutic approaches in the management of Type 2 diabetes is delaying the absorption of glucose through α-glucosidase enzymes inhibition, which can reduce the incidence of postprandial hyperglycemia. The existence of chronic postprandial hyperglycemia impaired the endogenous antioxidant defense due to inducing oxidative stress induced pancreatic β-cell destruction through uncontrolled free radicals generation such as ROS, which in turn, leads to various macrovascular and microvascular complications. This study aimed to synthesize 2-aryl-4,6-diarylpyrimidine derivatives, screen their α-glucosidase inhibitory activity, perform kinetic and molecular docking studies.

Methods

A series of 3,4,5-triphenyl-4,5-dihydro-1,2,4-oxadiazole derivatives were synthesize

SUBMITTER: Khosravi A 

PROVIDER: S-EPMC7214590 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature