Dendritic Spine and Synaptic Plasticity in Alzheimer's Disease: A Focus on MicroRNA.

ABSTRACT: Dendrites and dendritic spines are dynamic structures with pivotal roles in brain connectivity and have been recognized as the locus of long-term synaptic plasticity related to cognitive processes such as learning and memory. In neurodegenerative diseases, the spine dynamic morphology alteration, such as shape and spine density, affects functional characteristics leading to synaptic dysfunction and cognitive impairment. Recent evidence implicates dendritic spine dysfunction as a critical feature in the pathogenesis of dementia, particularly Alzheimer's disease. The alteration of spine morphology and their loss is correlated with the cognitive decline in Alzheimer's disease patients even in the absence of neuronal loss, however, the underlying mechanisms are poorly understood. Currently, th

SUBMITTER: Reza-Zaldivar EE 

PROVIDER: S-EPMC7214692 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature